Coexisting Polymorphisms of P2Y12 and CYP2C19 Genes as a Risk Factor for Persistent Platelet Activation With Clopidogrel

摘要: Background Coexisting polymorphisms of the genes affecting clopiogrel resistance may influence platelet activation. Methods and Results In 105 patients with acute coronary syndrome (ACS) treated percutaneous intervention, function was measured registered as closure time in test collagen adenosine diphosphate (CADP-CT). Patients were followed for 12 months death or recurrent myocardial infarction (MI). Genotyping revealed 7 carriers both C allele P2Y12 A CYP2C19 (group 1), 14 T 2), 17 G 3) 67 (controls). The median CADP-CT value significantly lower group 1 than 2 3 (p<0.01) controls (p<0.002), but did not differ between controls. There cardiovascular deaths 4 MI during follow-up, these (p=0.09). Conclusions Coexisting, rather then single, different be related to persistent activation while on clopidogrel, which raises concern about harm ACS. (Circ J 2008; 72: 1165 - 1169)