Polyamine Catabolism in Prokaryotes

摘要: Polyamines play important roles in cell growth and proliferation. In particular, these biogenic compounds are involved the regulation of transcription translation processes required for bacterial Consequently, intracellular polyamine content is strictly regulated at several levels, including biosynthesis, degradation, uptake from excretion into environment. this chapter, we discuss catabolism prokaryotes, focusing on well-studied pathway Escherichia coli. E. coli catabolizes putrescine to succinate via γ-aminobutyraldehyde (GABA) through aminotransferase or γ-glutamylate (the Puu pathway). Excess spermidine acetylated yield acetylspermidine, but whether metabolite then excreted cells, as it eukaryotes, not clear. Pseudomonas aeruginosa POA1, contrast coli, has expanded catabolic pathways salvage cadaverine carbon nitrogen sources.