Effects of aging and alterations in dietary sodium intake on total nitric oxide production

摘要: Abstract Animal studies suggest that nitric oxide (NO) deficiency is linked to salt-sensitive hypertension and NO activity decreases during normal aging. This study investigates the impact of increasing age manipulations in dietary salt intake on biochemical indices system healthy humans. We measured 2 + 3 (NO x ; stable oxidation products NO) cyclic guanosine monophosphate (cGMP; major second messenger) plasma urine 30 subjects aged 22 77 years. Subjects were maintained controlled low low-, normal-, or high-salt diets for days. Salt sensitivity blood pressure was seen only oldest subjects. Plasma renin suppressed by a high all groups, baseline values declined with advancing age. Neither nor correlated over third 24-hour period intake. In subgroup 33 ± 4 years challenged ultrahigh sodium (400 mEq/24 h), again there no increase N0 cGMP measures. contrast animal studies, correlation humans between either total production activity, indicated does not preclude undetected alterations occurring and/or strategic locations kidney cardiovascular system. Limitations measurements as are discussed.