Risks and Benefits of Therapies for Apnoea in Premature Infants

摘要: Apnoea in infants can result from a wide range of causes, and requires thorough evaluation before deciding on appropriate treatment. Continuous monitoring premature with apnoea is mandatory order to define the pathophysiology type apnoea; selection treatment involves careful assessment aetiology, as well efficacy tolerability each individual case. The objective prevent deleterious consequences apnoeas that last >20 seconds and/or are associated bradycardia, cyanosis or pallor, occur more often than once an hour over 12-hour period. management both pharmacological nonpharmacological We suggest methylxanthines first-line therapy for idiopathic apnoeas; evidence suggests caffeine better tolerated efficacious theophylline (since it particularly against ‘central’ component prematurity). If fails, additional measures such doxapram may be when hypoventilation present, nasal continuous positive airway pressure upper instability obstructive predominant. prophylaxis reason advocate prenatal maturation betamethasone. Weaning attempted 4 5 days after complete resolution apnoea, beginning introduced. Monitoring should maintained detect any relapse recurrent severe apnoeas, which would lead resumption most recently withdrawn