Liver function and the diagnostic significance of biochemical changes in the blood of African children with sickle cell disease.

摘要: The blood biochemistry of 84 young homozygous sickle cell patients aged 1 to 11 years was analysed for evidence liver disease. A comparison the values found in their with those seen normal children from an identical age group, assessed at same time, shows no convincing damage except 12% cases. transaminase observed many assessed, together high alkaline phosphatase activity which seemed be out proportion plasma bilirubin, is a picture compatible localised obstructive lesions or bone lesions, both are common This biochemical pattern suggests that conjugated dominates 40% who have 'haemolytic jaundice', due largely, not damage, but combination two factors, namely, intrahepatic cholestasis and presence actively functioning cells. Adequate albumin synthesis these patients, thymol reactions, provides further absence severe damage.