Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease

摘要: Background: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted study possible involvement of levels high-density lipoprotein cholesterol (HDL-C) in steadystate children SCD, once that this lipid marker has been correlated anti-inflammatory, anti-oxidative, antiaggregation, anti-coagulant pro-fibrinolytic activities, important aspects be considered pathogenesis. Methods: prospectively analyzed biochemical, inflammatory hematological 152 steady-state infants SCD 132 healthy subjects using immunochemistry, immunoassay electronic counter respectively. Clinical data were collected from patient medical records. Results: Of the investigated had significant positive association hemoglobin (P < 0.001), hematocrit 0.001) total negative reticulocytes = 0.046), leukocytes 0.015), monocytes 0.004) platelets 0.005), bilirubins [total bilirubin direct indirect 0.001], iron aminotransferases [aspartate aminotransferase 0.004), alanine 0.035)], lactate dehydrogenase urea 0.030), alpha 1-antitrypsin very low-density 0.003), triglycerides 0.005) S 0.002). Low concentration was associated history cardiac abnormalities 0.025), pneumonia 0.033) blood transfusion use 0.025). Lipids presence cholelithiasis. Conclusions: hypothesize some have specific dyslipidemic subphenotype characterized by low HDL-C hypertriglyceridemia high VLDL-C other biomarkers, including those related inflammation. This represents an step toward more reliable prognosis. Additional studies are warranted test hypothesis probably mechanisms involved complex network their role