Comparisons of carcinogenicities of nickel compounds in rats.

摘要: This study demonstrates marked differences in the incidences of sarcomas Fischer rats within 2 years after a single im injection 4 insoluble nickel-containing powders amorphous nickel monosulfide (NiS), subsulfide (..cap alpha..Ni/sub 3/S/sub 2/), partially converted nickel-iron sulfide matte, and metallic nickel. The (<2 ..mu..m median particle diameters) were administered penicillin suspension, each powder was tested at dosages. Whereas ..cap 2/ highly carcinogenic, NiS did not induce any tumors. carcinogenic potency matte less than but greater Ni powder. No occurred site two groups control that received injections or Fe observed potencies may provide an experimental approach to elucidate molecular mechanisms carcinogenesis.