Carcinogenesis Tests of Nickel Arsenides, Nickel Antimonide, and Nickel Telluride in Rats
作者： F. William Sunderman , Kilmer S. McCully
DOI: 10.3109/07357908309020271
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摘要: Carcinogenicity of nickel arsenides (NiAs, Ni11As8, Ni5As2, NiAsS), antimonide (NiSb), and telluride (NiTe) was tested by IM administration to male Fischer rats (14 mg Ni/rat). Three negative control groups received similar injections glycerol vehicle, ferronickel alloy (NiFe), or titanate (NiTiO3); two positive oxide (NiO) sulfide (Ni4FeS4) at equivalent dosages Within 2 years, the incidences sarcomas injection site were: 0120 (0%) in NiAs-treated rats, 8/16 (50%) Ni11As8-treated rats; 17/20 (85%) Ni5As2-treated 14/16 NiAsS-treated 17/29 (59%) NiSb-treated 14/26 (54%) NiTe-treated rats. No local occurred groups, including 40 glycerol-treated 16 NiFe-treated 20 NiTiO3-treated 14/15 (93%) NiO-treated 15/15 (100%) Ni4FeS4-treated The 9...
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