Adenovector-mediated gene delivery to human umbilical cord mesenchymal stromal cells induces inner ear cell phenotype.
作者： Keerthana Devarajan , M. Laird Forrest , Michael S. Detamore , Hinrich Staecker
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摘要: Abstract Hearing is one of our main sensory systems and having a hearing disorder can have significant impact in an individual's quality life. Sensory neural loss (SNHL) the most common form loss; it results from degeneration inner ear hair cells auditory neurons cochlea, that are terminally differentiated. Stem cell–and gene delivery–based strategies provide opportunity for replacement these cells. In recent years, there has been increasing interest delivery to mesenchymal stem this study, we evaluated potential human umbilical cord stromal (hUCMSCs) as possible source regenerating The expression Atoh1 induced differentiation hUCMSCs into resembled morphologically immunocytochemically, evidenced by cell–specific markers. demonstrated first time differentiate i...
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