Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears.

摘要: For mammalian cochlear hair cells, fate determination is normally completed by birth. We report here that overexpression of Math1, a mouse homolog the Drosophila gene atonal, in postnatal rat explant cultures resulted extra cells. Surprisingly, we found source ectopic cells was columnar epithelial located outside sensory epithelium greater ridge, which give rise to inner sulcus Moreover, Math1 expression also facilitated conversion utricular supporting into Thus sufficient for production ear, and immature ears retained competence generate new