The physiological disposition of lidocaine and its comparison in some respects with procaine.

摘要: The methyl orange method was applied for the determination of lidocaine in biological materials. Lidocaine found to be well absorbed when injected intramuscularly rat and addition epinephrine greatly slowed its absorption. One hour after given a rat, highest concentration kidney. Lung, spleen, fat, heart brain had appreciable levels whereas very low were present liver blood. disappeared rapidly from blood it intravenously. Only small fraction administered drug could recovered excreta. Liver chief organ metabolism lidocaine. difference between actions procaine can explained part by differences their physiological disposition.