Efficacy of enteral decontamination in the prevention of anastomotic dehiscence and pulmonary infection in esophagogastric surgery.
作者： L. Farran , J. Llop , M. Sans , E. Kreisler , M. Miró
DOI: 10.1111/J.1442-2050.2007.00764.X
关键词:
摘要: SUMMARY. Our aim in this study is to evaluate the efficacy of decontamination high digestive tract reducing incidence anastomotic dehiscence, pulmonary infection and mortality after resective gastro-esophageal surgery. A prospective randomized double-blinded was conducted patients undergoing total gastrectomy for gastric cancer esophagectomy esophageal cancer. Two groups were studied: group given erythromycin + gentamicine + nistatine sulfate orally; B placebo. Mortality, dehiscence end points evaluated. One hundred nine consecutive randomized. Eighteen (16.5%) excluded. From 91 who evaluated, 42 (46.2%) received an 49 (53.8%) had a gastrectomy. Esophagectomies showed: 0% rate 12.5% B, P = 0.176; 22.2% 29.1% P = 0.443; P = 0.176. After gastrectomy, 4.5% P = 0.449; 11.1% P = 0.387 9% P = 0.196. Decontamination protocol does not help decreasing present study. Nevertheless, there seems be tendency low improve esophagectomy. Further studies are needed re-evaluate these findings.
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