Sleep-Stage-Specific Regulation of Cortical Excitation and Inhibition
作者： Niels Niethard , Masashi Hasegawa , Takahide Itokazu , Carlos N. Oyanedel , Jan Born
DOI: 10.1016/J.CUB.2016.08.035
关键词:
摘要: Sleep is characterized by unique patterns of cortical activity alternating between the stages slow-wave sleep (SWS) and rapid-eye movement (REM) sleep. How these relate to balanced excitatory pyramidal cells inhibitory interneurons in circuits unknown. We investigated network during wakefulness, SWS, REM globally locally using in vivo calcium imaging mice. Wide-field revealed a reduction cell SWS compared with wakefulness and, unexpectedly, a further profound reduction Two-photon on local showed that this suppression was accompanied activation parvalbumin (PV)+ interneurons, but not somatostatin (SOM)+ interneurons. PV+ most active were also Our results reveal sleep-stage-specific regulation excitation/inhibition balance, conveying maximum inhibition sleep, which might help shape memories networks.
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