Local Integration Accounts for Weak Selectivity of Mouse Neocortical Parvalbumin Interneurons

摘要: Summary Dissecting the functional roles of excitatory and inhibitory neurons in cortical circuits is a fundamental goal neuroscience. Of particular interest are their emergent computations such as binocular integration primary visual cortex (V1). We measured response selectivity genetically defined subpopulations neurons. Parvalbumin (PV+) interneurons received strong inputs from both eyes but lacked for disparity. Because broad could result heterogeneous synaptic input neighboring neurons, we examined how individual PV+ interneuron compared to that local neuronal network, which is primarily composed showed similarity populations over spatial distances resembling measurements connectivity. On other hand, expressing CaMKIIα displayed no with population. Our findings suggest results nonspecific within networks. Video Abstract