Higher Glycemic Thresholds for Symptoms During β-Adrenergic Blockade in IDDM

摘要: We tested the hypotheses that nonselective β-adrenergic blockade does not cause absolute hypoglycemia unawareness but shifts glycemic thresholds for symptoms to lower plasma glucose concentrations and neither neuroglycopenic nor cognitive impairments during are altered by blockade. To do so, we applied euglycemic stepped hypoglycemic clamp techniques patients with moderately controlled insulin-dependent diabetes mellitus (IDDM) in absence ( n = 8) presence 9) of antagonist propranolol. Compared corresponding clamps, total symptom scores first increased at 4.4-mM step (a higher level than 2.8 mM nondiabetic subjects studied previously) did produce unawareness. Indeed, frankly mM, tended be This was largely result greater P 1 ) Nonselective IDDM. 2 reduce symptoms, it further impair function IDDM patients.