Deficit in parietal memory network underlies auditory hallucination: a longitudinal study

摘要: Auditory hallucination is a prominent and common symptom in schizophrenia. Previous neuroimaging studies have yielded mixed results of its brain network deficits. We proposed novel hypothesis that parietal memory network, centered at the precuneus, plays critical role auditory hallucination. This adjacent partially overlaps with default mode has been associated function familiarity labelling processing. Using longitudinal design large cohort first-episode, drug-naive schizophrenia patients, we examined this further investigated whether functional connectivity patterns can serve as marker for help to predict future treatment effects. Resting-state scans from 59 first-episode schizophrenic patients (27 32 without hallucination) 53 healthy control subjects were acquired baseline test, 56 them scanned again after two months. Functional strength within between hubs was across three groups follow-up scans. Results showed decreased specific group (p = 0.009, compare subjects; p 0.029, hallucination), precuneus representing largest difference. The intra-network negatively correlated severity scan (r -0.437, 0.029), it significantly increased two-month medication 0.039). Logistic regression analysis cross-validation test demonstrated precuneus-hippocampus could differentiate or sensitivity 0.750 specificity 0.708. Moreover, these imaging features well predicted extents positive improvement (R2 0.433, 0.022). Our provide evidence underlying hallucination, propose identifying accessing severity, prognosis effect