A comparative study of the interactions of cationic hetarenes with quadruplex-DNA forming oligonucleotide sequences of the insulin-linked polymorphic region (ILPR).
作者： Darinka Dzubiel , Heiko Ihmels , Mohamed M A Mahmoud , Laura Thomas
DOI: 10.3762/BJOC.10.314
关键词:
摘要: The interactions of the ILPR sequence (ILPR = "insulin-linked polymorphic region") a2 [d(ACAG4TGTG4ACAG4TGTG4)] with [2.2.2]heptamethinecyanine derivatives 1a–e and already established quadruplex ligands coralyne (2), 3,3′-[2,6-pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] (3), 4,4′,4′′,4′′′-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[1-methylpyridinium] (4), naphtho[2,1-b:3,4-b′:6,5-b′′:7,8-b′′′]tetraquinolizinium (5) thiazole orange (6) were studied. It is demonstrated absorption, fluorescence CD spectroscopy that all investigated bind relatively high affinity to ILPR-quadruplex DNA (0.2–5.5 × 106 M−1) in most cases binding parameters ligand-ILPR complexes are different from ones observed other native quadruplex-forming sequences.
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