Light up G-quadruplex DNA with a [2.2.2]heptamethinecyanine dye
作者： Heiko Ihmels , Laura Thomas
DOI: 10.1039/C2OB26779A
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摘要: The interactions of a triangle-shaped [2.2.2]heptamethinecyanine dye 1, namely 1,5,7-tris-[3-methylbenzothiazol-2-yl]-[2.2.2]heptamethindiium, with quadruplex DNA were studied photometric and fluorimetric titrations, thermal denaturation, CD 1H-NMR spectroscopy. ligand binds to the moderate affinity (K = 8 × 105 M−1), mainly by terminal π stacking. Remarkably, 1 exhibits selectivity for relative duplex DNA. Whereas cyanine is very weakly fluorescent in aqueous solution, emission intensity increases factor >100 upon association Thus, it shown that trinuclear derivatives may be employed as selective probes detection
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