Carrier-based dry powder formulation for nasal delivery of vaccines utilizing BSA as model drug
作者： Sabrina Trows , Regina Scherließ
DOI: 10.1016/J.POWTEC.2016.01.042
关键词:
摘要: Abstract Dry powder formulations for nasal vaccine delivery offer versatile advantages compared to liquid formulations, such as increased storage stability and simplified administration. The objective of the present study was development a dry formulation making use antigen-loaded chitosan microparticles. Special emphasis put on characterization which can realistically be used in humans by means sprayer. Microparticles with bovine serum albumin model antigen were produced spray drying showed particle size about 3 μm. In order improve deposition dispersibility, blends low separation tendency prepared. A range sugar alcohols (mannitol, sorbitol, maltitol) evaluated carriers. Among tested carriers, spray-granulated mannitol most adequate profile without simulated inspiration very well dispersible device. conclusion, this illustrates simple effective strategy
sci-hub.se 参考文章(38)
Ankur Ajmera, Regina Scherließ, Stabilisation of proteins via mixtures of amino acids during spray drying International Journal of Pharmaceutics. ,vol. 463, pp. 98- 107 ,(2014) , 10.1016/J.IJPHARM.2014.01.002
Mi Lan Kang, Chong Su Cho, Han Sang Yoo, Application of chitosan microspheres for nasal delivery of vaccines. Biotechnology Advances. ,vol. 27, pp. 857- 865 ,(2009) , 10.1016/J.BIOTECHADV.2009.06.007
Regina Scherließ, Mathias Mönckedieck, Katherine Young, Sabrina Trows, Simon Buske, Sarah Hook, First in vivo evaluation of particulate nasal dry powder vaccine formulations containing ovalbumin in mice International Journal of Pharmaceutics. ,vol. 479, pp. 408- 415 ,(2015) , 10.1016/J.IJPHARM.2015.01.015
Giuseppe Curigliano, Maria Rescigno, Aron Goldhirsch, Immunology and breast cancer: therapeutic cancer vaccines. The Breast. ,vol. 16, pp. 20- 26 ,(2007) , 10.1016/J.BREAST.2007.07.004
Kim Pannemans, Niels Hellings, Piet Stinissen, Therapeutic vaccines for autoimmune Diseases Drug Discovery Today: Therapeutic Strategies. ,vol. 6, pp. 39- 44 ,(2009) , 10.1016/J.DDSTR.2009.11.001
Mayank D Bhavsar, Mansoor M Amiji, Polymeric nano- and microparticle technologies for oral gene delivery. Expert Opinion on Drug Delivery. ,vol. 4, pp. 197- 213 ,(2007) , 10.1517/17425247.4.3.197
Charalambos D. Partidos, Intranasal vaccines: forthcoming challenges. Pharmaceutical Science & Technology Today. ,vol. 3, pp. 273- 281 ,(2000) , 10.1016/S1461-5347(00)00281-9
Duane T. Brandau, Latoya S. Jones, Christopher M. Wiethoff, Jason Rexroad, C.Russell Middaugh, Thermal Stability of Vaccines Journal of Pharmaceutical Sciences. ,vol. 92, pp. 218- 231 ,(2003) , 10.1002/JPS.10296
Noemi Csaba, Marcos Garcia-Fuentes, Maria Jose Alonso, None, Nanoparticles for nasal vaccination. Advanced Drug Delivery Reviews. ,vol. 61, pp. 140- 157 ,(2009) , 10.1016/J.ADDR.2008.09.005
Niels Mygind, Ronald Dahl, Anatomy, physiology and function of the nasal cavities in health and disease Advanced Drug Delivery Reviews. ,vol. 29, pp. 3- 12 ,(1998) , 10.1016/S0169-409X(97)00058-6