The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold.

作者: Muharrem Akcan , Ying Cao , Fan Chongxu , David J. Craik

DOI: 10.1016/J.BMC.2013.02.012

关键词:

摘要: … In the current study, we report the disulfide connectivity, chemical synthesis and the 3D solution structure of another mini-M conotoxin BtIIIA, a 14-residue peptide purified from the …

参考文章(30)
Wei Kh, Chen Js, Fan Cx, Zhong Mn, Hu Kp, Studies on conotoxins of Conus betulinus. Journal of Natural Toxins. ,vol. 8, pp. 341- ,(1999)
Kurt Wuthrich, NMR of proteins and nucleic acids ,(1986)
L J Cruz, B M Olivera, Calcium channel antagonists. Omega-conotoxin defines a new high affinity site. Journal of Biological Chemistry. ,vol. 261, pp. 6230- 6233 ,(1986) , 10.1016/S0021-9258(19)84552-0
Wei-Hong Du, Yu-Hong Han, Fei-juan Huang, Juan Li, Cheng-Wu Chi, Wei-Hai Fang, Solution structure of an M-1 conotoxin with a novel disulfide linkage FEBS Journal. ,vol. 274, pp. 2596- 2602 ,(2007) , 10.1111/J.1742-4658.2007.05795.X
W.R. Gray, A. Luque, B.M. Olivera, J. Barrett, L.J. Cruz, Peptide toxins from Conus geographus venom. Journal of Biological Chemistry. ,vol. 256, pp. 4734- 4740 ,(1981) , 10.1016/S0021-9258(19)69313-0
Niels Skjærbæk, Katherine J. Nielsen, Richard J. Lewis, Paul Alewood, David J. Craik, Determination of the Solution Structures of Conantokin-G and Conantokin-T by CD and NMR Spectroscopy Journal of Biological Chemistry. ,vol. 272, pp. 2291- 2299 ,(1997) , 10.1074/JBC.272.4.2291
Axel T Brünger, Paul D Adams, G Marius Clore, Warren L DeLano, Piet Gros, Ralf W Grosse-Kunstleve, J-S Jiang, John Kuszewski, Michael Nilges, Navraj S Pannu, Randy J Read, Luke M Rice, Thomas Simonson, Gregory L Warren, Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination Acta Crystallographica Section D-biological Crystallography. ,vol. 54, pp. 905- 921 ,(1998) , 10.1107/S0907444998003254
Justine M. Hill, Paul F. Alewood, David J. Craik, Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry. ,vol. 35, pp. 8824- 8835 ,(1996) , 10.1021/BI960073O
Carsten K. Nielsen, Richard J. Lewis, Dianne Alewood, Roger Drinkwater, Elka Palant, Margaret Patterson, Tony L. Yaksh, Damon McCumber, Maree T. Smith, Anti-allodynic efficacy of the χ-conopeptide, Xen2174, in rats with neuropathic pain Pain. ,vol. 118, pp. 112- 124 ,(2005) , 10.1016/J.PAIN.2005.08.002
Owen M. McDougal, C. Dale Poulter, Three-dimensional structure of the mini-M conotoxin mr3a. Biochemistry. ,vol. 43, pp. 425- 429 ,(2004) , 10.1021/BI0353732