Endothelium-dependent vasodilation of the skin microcirculation in heart transplant recipients.

摘要: Patients with heart failure demonstrate attenuated endothelium-dependent vasodilation of the peripheral circulation, while this is suggested to be reversed after transplantation. However, data from human subjects are limited and conflict studies on vasomotor tone in cyclosporine-treated animals, suggesting endothelial dysfunction. We recorded forearm skin perfusion responses following graded iontophoresis 1% acetylcholine (endothelium-dependent) sodium nitroprusside (endothelium-independent) by laser Doppler measurements 32 transplant recipients 15 age-matched controls. In addition, hyperemic response 3 min blood flow occlusion was measured third finger pulp. With comparable baseline values, increases 4 applications were significantly compared controls: 59 +/- 9 vs. 146 32, 242 39 492 77, 480 66 845 120 699 77 993 139% (mean SEM; all p < 0.01). Peak hyperemia (134 153 12 arbitrary units (AU); 0.05)), time for return preocclusive (52.4 102.9 s; 0.01) hence area under curve (1469 244 4581 921 AU reduced among recipients. The correlated mean arterial pressure (r = -0.60; 0.41; Two non-invasive tests vascular function endothelial-dependent microvascular relative impact prior congestive postoperative factors, such as treatment cyclosporine, remains determined.