Useful combinations of monobactam antibiotics with beta-lactamase inhibitors

作者: Bérangère Gaucher , Patrick Roussel , Eric Desarbre , Malcolm G. P. Page

DOI:

关键词:

摘要: A pharmaceutical composition, comprising a combination of an antibiotically active compound the formula (I): with s-lactamase inhibitor one formulae (II) to (XIII) are against Gram-negative bacteria, in particular such bacteria which have become resistant antibiotics as aztreonam, carumonam and tigemonam. Optionally compositions may comprise another (XIII), particularly (V) or (VI).

参考文章(135)
Claude Fromentin, David Alan Rowlands, Maxime Lampilas, Jozsef Aszodi, Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents ,(2001)
Charles Fiakpui, Andhe V. Narender Reddy, Samarendra Nath Maiti, George Thomas, Rajeshwar Singh, Ronald George Micetich, Sameeh M. Salama, 3-(Heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents ,(2001)
Jeffrey Besterman, Arkadii Vaisburg, Jubrail Rahil, Novel inhibitors of beta-lactamase ,(2007)
Fusahiro Higashitani, Eduardo L. Setti, Tatsuya Uji, Koichi Nishida, Oludotun A. Phillips, Andhe V. Narender Reddy, Chieko Kunugita, Rajeshwar Singh, Ronald George Micetich, Samarendra N. Maiti, 2-oxo-1-azetidine sulfonic acid derivatives as potent beta-lactamase inhibitors ,(1998)
FUMIO YONEDA, SADAO NISHIGAKI, KEITARO SENGA, KYOKO AIDA, TOYOMI TAKABATAKE, Condensation Reactions of Ethyl Ethoxymethylenecyanoacetate with Amidines Chemical & Pharmaceutical Bulletin. ,vol. 18, pp. 1003- 1007 ,(1970) , 10.1248/CPB.18.1003
Taisuke Matsuo, Michihiko Ochiai, Shoji Kishimoto, 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production ,(1983)
William H. Koster, Richard B. Sykes, Christopher M. Cimarusti, William L. Parker, William A. Slusarchyk, 2-oxo-1-azetidinesulfonic acid salts ,(1981)