Modeling the mechanical consequences of vibratory loading in the vertebral body: microscale effects.

摘要: Osteoporosis affects nearly 10 million individuals in the United States. Conventional treatments include anti-resorptive drug therapies, but recently, it has been demonstrated that delivering a low magnitude, dynamic stimulus via whole body vibration can have an osteogenic effect without need for large magnitude strain stimulus. Vibration of vertebral induces range stimuli may account anabolic response including strains, interfacial shear stress due to marrow movement, and blood transport. In order evaluate relative importance these stimuli, we integrated microstructural model cancellous bone with mixture theory body. The predicted stresses on surfaces trabeculae during vibratory loading are values considered be stimulatory increase increasing solid volume fraction. Peak volumetric flow rates also varied amplitude frequency, exhibited little dependence These results suggest fluid governs vertebrae viscosity is critical parameter which modulates stress.