作者: Kazuo Murakami , Akiyoshi Fukamizu
DOI: 10.1016/S0162-3109(99)00142-3
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摘要: The renin-angiotensin system, composed of enzymatic and signal-transduction cascades, plays a key role in the regulation arterial blood pressure development certain forms experimental human hypertension. products this angiotensin peptides, exert wide range physiologically important effects on many tissues, including those cardiovascular systems, through their actions receptors. Molecular genetic transgenic studies have begun to implicate some genes encoding components system diseases. Recently, we succeeded generating mice with chronic hypertension inducible during pregnancy creating homozygous for targeted disruption angiotensinogen gene (the only known precursor angiotensins), resulting complete loss signals vivo. Here, will review recent advances related functional analysis particular by focusing approaches targeting.