Relationship Between the Early Arterial Reaction to Hypertension and the Development of Intimal Proliferation

摘要: Summary Malignant renal hypertension was induced in male Wistar rats. In the early phase of disease, ie. 1st week, a transient and generalized activation arterial cellular functions observed, while later, on day 21 widespread intimal proliferations developed arteries. This included an increase transmural permeability, DNA-, protein, collagen, elastin ground substance synthesis, rise mural PGI 2 content number Weibel-Palade bodies. An platelets monocytes could also be detected during week. group rats development malignant interrupted following arteries incidence compared with that maintained hypertension. No proliferation observed It is concluded artery does not furnish enough stimulus for triggering plaques are direct sequelae reaction. Furthermore entrance plasma materials permeability can induce smooth muscle if interrupted.