Mechanism of long-term degeneration of arterialized vein grafts.
作者： Ted R. Kohler , Thomas R. Kirkman , David Gordon , Alexander W. Clowes
DOI: 10.1016/S0002-9610(06)80018-8
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摘要: This study examined long-term changes in the morphology and cellular kinetics of rabbit vein grafts transplanted into cartoid artery. Six were studied 1 year after implantation. Although circumference thickness wall not different than at 12 weeks, degenerative occurred. The endothelial lining graft appeared intact, but large segments surface no longer excluded Evans blue dye, suggesting increased permeability. Collections red blood cells noted within intima. Several had extensive subendothelial fibrin deposits, often associated with foam cells, evidence previous hemorrhage, these did stimulate significant smooth muscle cell proliferation. Increased permeability entrance proteins erythrocytes intima may result from tension or low shear rates wall. Similar lead to atherosclerosis human late times.
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