Effects of hyperbaric oxygen on GDNF expression and apoptosis in spinal cord injury.
作者： Yimin Yu , Yukihiro Matsuyama , Makoto Yanase , Sachiko Ito , Kayo Adachi
DOI: 10.1097/00001756-200410250-00014
关键词:
摘要: The effects of hyperbaric oxygen treatment on the progress secondary damage following traumatic spinal cord injury were investigated. early onset significantly diminished number apoptotic cells 1 day after injury. However, did not influence proliferation macrophages or activated microglia. gene expression glial cell line-derived neurotrophic factor (GDNF) and inducible nitric oxide synthetase (iNOS) was attenuated in groups compared with control group. down-regulation confirmed by immunohistochemical staining. Early shown to effectively suppress apoptosis perhaps via inhibition iNOS despite GDNF gene.
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