Short Term Interactions in Animal Cell Heterokaryons Leading to Induction of DNA Synthesis and Premature Chromosome Condensation

作者: Robert T. Johnson , Potu N. Rao

DOI: 10.1016/B978-0-08-017290-3.50022-5

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摘要: Fusion between cells in different phases of the cell cycle can result induction DNA synthesis and premature chromosome condensation. Of fusions mitotic interphase complementing auxotrophic mutants Chinese hamster cells, S phase fusion gave lowest rate hybrid survival greatest loss chromosomes. It is proposed that use be made internal asynchrony multinucleate immediately after for directional chromosomes from progeny.

参考文章(13)
R. T. Johnson, P. N. Rao, Premature chromosome condensation: a mechanism for the elimination of chromosomes in virus-fused cells. Journal of Cell Science. ,vol. 10, pp. 495- 513 ,(1972)
R. T. Johnson, P. N. Rao, H. D. Hughes, Mammalian cell fusion III. A hela cell inducer of premature chromosome condensation active in cells from a variety of animal species Journal of Cellular Physiology. ,vol. 76, pp. 151- 157 ,(1970) , 10.1002/JCP.1040760204
A WESTERVELD, M FREEKE, Cell cycle of multinucleate cells after cell fusion. Experimental Cell Research. ,vol. 65, pp. 140- 144 ,(1971) , 10.1016/S0014-4827(71)80059-9
F.-T. Kao, R. T. Johnson, T. T. Puck, Complementation Analysis on Virus-Fused Chinese Hamster Cells with Nutritional Markers Science. ,vol. 164, pp. 312- 314 ,(1969) , 10.1126/SCIENCE.164.3877.312
F.-T. Kao, L. Chasin, T. T. Puck, Genetics of somatic mammalian cells. X. Complementation analysis of glycine-requiring mutants. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 64, pp. 1284- 1291 ,(1969) , 10.1073/PNAS.64.4.1284
POTU N. RAO, ROBERT T. JOHNSON, Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis Nature. ,vol. 225, pp. 159- 164 ,(1970) , 10.1038/225159A0
A. G. SCHWARTZ, P. R. COOK, HENRY HARRIS, Correction of a genetic defect in a mammalian cell. Nature. ,vol. 230, pp. 5- 8 ,(1971) , 10.1038/NEWBIO230005A0
Saimon Gordon, Zanvil Cohn, Macrophage-melanocyte heterokaryons. I. Preparation and properties. Journal of Experimental Medicine. ,vol. 131, pp. 981- 1003 ,(1970) , 10.1084/JEM.131.5.981