Evolution of Protein Wrapping and Implications for the Drug Designer

摘要: Proteins with common ancestry (homologs) typically share a fold. This structural similarity introduces major problems for rational drug design since goal in the field is control of specificity. Yet, as shown this chapter, while topology native structure extremely similar across homologs, their wrapping patterns and expression regulation tend to be different, offering novel opportunity funnel impact on clinically relevant targets. The evolutionary root these dissimilarities homologous proteins carefully dissected chapter both species within human species. Furthermore, hinted demonstrated subsequent chapters, variations homologs have profound consequences we aim at engineering target-specific species-specific therapeutic agents build insightful animal models disease or malignancy.