Proton conduction through proteins: an overview of theoretical principles and applications.

摘要: Publisher Summary This chapter provides an overview of theoretical principles and applications proton conduction through proteins. The currents in biological systems involve only a small percentage the atoms composing system bonds conductors are constantly being broken by reorientation conducting groups. These two aspects transport make its detection exceedingly difficult. Two studied membrane protein bacteriorhodopsin, which functions as light-driven pump Halobacterium halobium, proteolipid ATPase, passive conductor. constituents conductor most likely molecules bound water or polar amino acid side groups protein. molecular dynamics calculations on ion channel gramicidin indicate that linear may be pathway channels well. observables suitable to elucidate structure function summarized chapter.