Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA.

作者: Maura Dandri , Martin R. Burda , Hans Will , Joerg Petersen

DOI: 10.1053/JHEP.2000.8701

关键词:

摘要: … , to determine whether the pool of covalently closed circular DNA (cccDNA) could be reduced by … -treated hepatocyte cultures even when cell turnover was induced for 14 days by the …

参考文章(29)
M. Roggendorf, T.K. Tolle, The Woodchuck: An Animal Model for Hepatitis B Virus Infection in Man Intervirology. ,vol. 38, pp. 100- 112 ,(1995) , 10.1159/000150418
X X Fu, C Y Su, Y Lee, R Hintz, L Biempica, R Snyder, C E Rogler, Insulinlike growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriers. Journal of Virology. ,vol. 62, pp. 3422- 3430 ,(1988) , 10.1128/JVI.62.9.3422-3430.1988
B. S. Blumberg, Hepatitis B virus, the vaccine, and the control of primary cancer of the liver Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 7121- 7125 ,(1997) , 10.1073/PNAS.94.14.7121
Manuel Tsiang, James F. Rooney, John J. Toole, Craig S. Gibbs, Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy Hepatology. ,vol. 29, pp. 1863- 1869 ,(1999) , 10.1002/HEP.510290626
BE Petersen, WC Bowen, KD Patrene, WM Mars, AK Sullivan, Net al Murase, SS Boggs, JS Greenberger, JP Goff, Bone Marrow as a Potential Source of Hepatic Oval Cells Science. ,vol. 284, pp. 1168- 1170 ,(1999) , 10.1126/SCIENCE.284.5417.1168
MA Buendia, Hepatitis B viruses and cancerogenesis. Biomedicine & Pharmacotherapy. ,vol. 52, pp. 34- 43 ,(1998) , 10.1016/S0753-3322(97)86239-7
Carol E. Aldrich, Laura Coates, Tsung-Teh Wu, John Newbold, Bud C. Tennant, Jesse Summers, Christoph Seeger, William S. Mason, In vitro infection of woodchuck hepatocytes with woodchuck hepatitis virus and ground squirrel hepatitis virus. Virology. ,vol. 172, pp. 247- 252 ,(1989) , 10.1016/0042-6822(89)90126-8