Angiotensin type 2 receptors in the cardiovascular system
作者： Carmine Savoia , Ernesto L Schiffrin
DOI: 10.2165/00151642-200714020-00002
关键词:
摘要: Angiotensin II (Ang II) exerts its effects by acting on two receptors: the angiotensin type 1 receptor (AT1R) and 2 (AT2R). Whereas AT1R seems to mediate most of recognised actions Ang II, it appears that AT2R opposes, in part, mediated AT1R. may have homeostatic role exerting a countervailing influence excess stimulation Since is expressed adult tissues smaller numbers than AT1R, cell signalling been less well characterised those In vitro vivo studies show mediates vasodilation, antigrowth proapoptotic effects. also modulates progression atherosclerosis. A protective cardiovascular system has confirmed humans, mainly during chronic inhibition, which contribute part mechanism action blockers.
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