Fatigue is highly associated with poor health-related quality of life, disability and depression in newly-diagnosed patients with inflammatory bowel disease, independent of disease activity

摘要: SummaryBackground Fatigue is common in Crohn's disease (CD) and ulcerative colitis (UC). Data on fatigue newly diagnosed patients are unavailable. Aim To report prevalence of CD UC examine its association with health-related quality life (HRQOL), depression disability. Methods The Ocean State Colitis Area Registry (OSCCAR) a statewide cohort inflammatory bowel Rhode Island. Fatigue was assessed using the Functional Assessment Chronic Illness Therapy-Fatigue Scale. Patients were administered instruments measuring HRQOL, overall disability work impairment, depression. Results Fatigue prevalent 26.4% 220 subjects. Cohen's d effect sizes for large: Short-Form 36 Health Survey mental health component (CD 1.5, 1.4) physical 1.4, 1.4), EuroQol-5D valuation current state 1.2, 1.0), Inflammatory Bowel Disease Questionnaire 1.9, 1.6) Patient scale 1.8, 1.7). Fatigued reported more impairment (Score difference: 29.5%, 23.8%) activity (score 32.3%, 25.7%) Work Productivity Activity Impairment Questionnaire. Fatigue's all scores remained highly significant despite controlling activity. Conclusions Fatigue strongly associated poor similarly even when activity. wide range patient-reported outcome measures suggests that monitoring simple way to screen disruption patient life.