The Role of Phosphorylation in Growth Control and Malignant Transformation

摘要: Experiments with cultured cells suggest that the growth of mammalian is regulated largely by factors and inhibitors acting at G0/G1 border in cell cycle. Growth are mostly polypeptide nature (e.g. EGF, PDGF, FGF, IGF-1, bombesin) range mass from 2,000 to 70,000 daltons. Cells responsive a given factor have specific surface receptors, usually numbering between 103 106 per cell, high affinity (Kd 10-8 10-11) specificity for their ligand. Occupancy these receptors results transduction signal across membrane cytoplasm, which will be discussed below. Bona fide only recently been purified homogeneity TGF-β, interferon), although existence had surmised many years. Their mode action not understood, but, like factors, presumably transduce signals cytoplasm. Another external component essential extracellular matrix, comprised proteins fibronectin, laminin, collagen, glycosaminoglycans. Adherent grow absence an but most capable elaborating own matrix. There matrix proteins, it yet known whether binding ligand this type receptor causes event.