作者: Tony Hunter , Jonathan A. Cooper
DOI: 10.1016/S1874-6047(08)60431-X
关键词:
摘要: Publisher Summary This chapter describes viral protein-tyrosine kinases and discusses their roles in transformation. For this, the properties of individual are described contrasted to cognate cellular enzymes that encoded by genes homologous oncogenes. The a number transformed cell types where altered tyrosine phosphorylation is evident general common structural features. In addition, includes progress report on identification substrates for kinases. way which differ from counterparts—enzymes clearly coexist peaceably with normal cells. chapter, compared those growth factor receptor kinases, particularly because abnormal state