Distinct homologous recombination gene expression profiles after neoadjuvant chemotherapy associated with clinical outcome in patients with ovarian cancer
作者： Roy Kessous , David Octeau , Kathleen Klein , Patricia N. Tonin , Celia M.T. Greenwood
DOI: 10.1016/J.YGYNO.2018.01.017
关键词:
摘要: Abstract Objective The expression of homologous recombination (HR) genes in high grade ovarian cancer (HGOC) samples from debulking surgeries were correlated to outcomes patients selected for chemotherapy treatment regimens. Study design RNA was extracted 96 fresh frozen tumor naive with HGOC (primary derived (PDS), n = 55) or following neoadjuvant (NACT), = 41). content by a gynecological pathologist, and cell further confirmed using percent covariate, mutation score covariate analysis. Gene analysis performed tailored NanoString-based Pancancer Pathway Panel. Cox proportional hazard regression models used assess the associations between 19 HR survival. Results In PDS group, over-expression six (C11orf30, NBN, FANCF, FANCC, FANCB, RAD50) associated improved outcome, contrast NACT group where four (BRCA2, TP53, RAD51) worse outcome. With adding extent as three (NBN, RAD50), only one gene (RAD51) remained significantly survival groups, respectively. Conclusion Distinct profiles define subgroups overall outcome that are exposed not chemotherapy-naive patients.
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