Mexiletine: a review of its pharmacological properties and therapeutic efficacy in arrhythmias.

摘要: Mexiletine is a new local anaesthetic antiarrhythmic agent whose chemical structure and electrophysiological properties closely resemble those of lignocaine although its anticonvulsant pharmacokinetic differ from that drug. Unlike (lidocaine) it active following oral administration with plasma half-life varying between 8 20 hours so can be administered twice or three times daily to sustain therapeutic levels. The drug effective when given intravenously by the route in controlling ventricular arrhythmias especially acute myocardial infarction but side effects are greater during parenteral administration. Side chronic therapy mexiletine have not posed serious problem. has pharmacodynamic an suitable for prophylaxis patients ischaemic heart disease.