Gene expression profiles at different stages of human esophageal squamous cell carcinoma
作者： Jin Zhou , Li-Qun Zhao , Mo-Miao Xiong , Xiu-Qin Wang , Guan-Rui Yang
DOI: 10.3748/WJG.V9.I1.9
关键词:
摘要: AIM: To characterize the gene expression profiles in different stages of carcinogenesis esophageal epithelium. METHODS: A microarray containing 588 cancer related genes was employed to study profile at squamous cell carcinoma including basal hyperplasia, high-grade dysplasia, situ, early and late cancer. Principle component analysis performed search which were important carcinogenesis. RESULTS: More than 100 up or down regulated epithelial cells during identified a set may play roles tumor development. Comparison between these showed that some genes, such as P160ROCK, JNK2, activated an role carcinogenesis. CONCLUSION: These findings provided cancer-specific stage-specific profiles, showing complex alterations underlie development malignant phenotype cells.
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