Preclinical Molecular Imaging of Tumor Angiogenesis

摘要: Angiogenesis, a course that new blood vessels grow from the existing vasculature, plays important roles both physiologically and pathologically. Angiogenesis can be switched on by growth factors secreted tumor cells, in turn supplies more oxygen nutrition to tumor. More preclinical studies clinical trials have shown inhibition of angiogenesis is an effective way inhibit growth, substantiating development anti-angiogenesis therapeutics. Imaging technologies accelerate translation research clinic. In oncology, various imaging modalities are widely applied drug development, early detection therapy response monitoring. So far, several related agents promising cancer diagnosis. However, with less side-effect still need pursued visualize process non-invasively. The main purpose this review summarize recent progresses molecular discuss potential current probes specific targets including vascular endothelial factor its receptors (VEGF/VEGFRs), integrin avb3 matrix metalloproteinases (MMPs). It predictable investigations field will benefit quicken anti-angiogenic development.