Antivascular Endothelial Growth Factor Receptor (Fetal Liver Kinase 1) Monoclonal Antibody Inhibits Tumor Angiogenesis and Growth of Several Mouse and Human Tumors
作者： Bronislaw Pytowski , William O’Connor , Daniel J. Hicklin , Andrea Hooper , Yiwen Li
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摘要: … tumor angiogenesis. Previously, we reported on the development of anti-Flk-1 and antikinase insert domain-containing receptor monoclonal … DC101) on angiogenesis and tumor growth. …
aacrjournals.org参考文章(53)
R. Pili, A. Passaniti, G. R. Martin, D. S. Grant, R. M. Taylor, P. V. Long, Y. Guo, R. R. Pauly, J. A. Haney, A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Laboratory Investigation. ,vol. 67, pp. 519- 528 ,(1992)
H. F. Dvorak, J. A. Nagy, D. Feng, L. F. Brown, A. M. Dvorak, Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Current Topics in Microbiology and Immunology. ,vol. 237, pp. 97- 132 ,(1999) , 10.1007/978-3-642-59953-8_6
S. Tessler, P. Rockwell, D. Hicklin, T. Cohen, B.Z. Levi, L. Witte, I.R. Lemischka, G. Neufeld, Heparin modulates the interaction of VEGF165 with soluble and cell associated flk-1 receptors. Journal of Biological Chemistry. ,vol. 269, pp. 12456- 12461 ,(1994) , 10.1016/S0021-9258(18)99896-0
Corazon D. Bucana, Yasuhiko Kitadai, Karen R. Cleary, Lee M. Ellis, Yutaka Takahashi, Expression of Vascular Endothelial Growth Factor and Its Receptor, KDR, Correlates with Vascularity, Metastasis, and Proliferation of Human Colon Cancer Cancer Research. ,vol. 55, pp. 3964- 3968 ,(1995)
Susan Fuggle, Roy Bicknell, David Cranston, Tim O'Brien, Adrian L. Harris, Different Angiogenic Pathways Characterize Superficial and Invasive Bladder Cancer Cancer Research. ,vol. 55, pp. 510- 513 ,(1995)
Larry Witte, Daniel J. Hicklin, Zhenping Zhu, Bronislaw Pytowski, Helen Kotanides, Patricia Rockwell, Peter Böhlen, Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy. Cancer and Metastasis Reviews. ,vol. 17, pp. 155- 161 ,(1998) , 10.1023/A:1006094117427
Helena J. Mauceri, Nader N. Hanna, Michael A. Beckett, David H. Gorski, Mary-Jane Staba, Kerri Anne Stellato, Kevin Bigelow, Ruth Heimann, Stephen Gately, Mohanraj Dhanabal, Gerald A. Soff, Vikas P. Sukhatme, Donald W. Kufe, Ralph R. Weichselbaum, Combined effects of angiostatin and ionizing radiation in antitumour therapy Nature. ,vol. 394, pp. 287- 291 ,(1998) , 10.1038/28412
Michael Schirner, Andreas Menrad, Martin R. Schneider, Jens Hoffmann, A Highly Sensitive Model for Quantification of in Vivo Tumor Angiogenesis Induced by Alginate-encapsulated Tumor Cells Cancer Research. ,vol. 57, pp. 3847- 3851 ,(1997)
Kuniko Kawaishi, Yukio Satow, Osamu Katoh, Akiro Kimura, Hiroshi Tauchi, Expression of the Vascular Endothelial Growth Factor (VEGF) Receptor Gene, KDR, in Hematopoietic Cells and Inhibitory Effect of VEGF on Apoptotic Cell Death Caused by Ionizing Radiation Cancer Research. ,vol. 55, pp. 5687- 5692 ,(1995)
Eleanor J. Manseau, Brygida Berse, Kathi Tognazzi, Donald R. Senger, Lawrence F. Brown, Harold F. Dvorak, Robert W. Jackman, Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) and Its Receptors in Adenocarcinomas of the Gastrointestinal Tract Cancer Research. ,vol. 53, pp. 4727- 4735 ,(1993)