Interactions between multiple helminths and the gut microbiota in wild rodents.

摘要: The gut microbiota is vital to host health and, as such, it important elucidate the mechanisms altering its composition and diversity. Intestinal helminths are immunomodulators have evolved both temporally spatially in close association with microbiota, resulting potential mechanistic interplay. Host–helminth host–microbiota interactions comparatively well-examined, unlike microbiota–helminth relationships, which typically focus on experimental infection a single helminth species laboratory animals. Here, addition review of literature helminth–microbiota interactions, we examined empirically between diversity natural multiple wild mice (Apodemus flavicollis), using 16S rRNA gene catalogues (metataxonomics). In general, presence linked high diversity, may confer benefits host. Within our rodent system variation abundance microbial taxa associated was specific each occurred up- downstream given helminth's niche (gut position). most pronounced tapeworms small intestine increased S24–7 (Bacteroidetes) family stomach. Helminths clearly alter homeostasis. Free-living rodents diverse community offer useful model that enables correlative (this study) manipulative inference interactions.