Atrial and ventricular isomyosin composition in patients with different forms of cardiac hypertrophy.

摘要: In man, various forms of compensatory and idiopathic hypertrophic states can be differentiated by haemodynamic angiographic parameters. They are morphologically indistinguishable with regard to muscle fibre diameter non-muscle tissue content. are, however, accompanied contractile dysfunction degrees or even hypercontractility. hearts subjected chronic increase in workload the peptide pattern slow ventricular myosin heavy chain (HC) type VM-3 does not change, while that fast atrial HC does. atria also light chain-2 (VLC-2) is occurring. certain hypertrophy we found ALC-1 occurring tissue, individual cases amounting 30% total LC-1, on average, 12% dilated cardiomyopathy, 6% pressure 3% volume overload 2% reduced myocardial mass due infarction. No such was cardiomyopathy coronary heart disease without The isoform expression LC thus governed independently one another response altered physiological pathological conditions. A significant correlation content ventricles could established peak circumferential wall stress. This may imply involvement LC-1 properties myofibrils.