Administration of an Immune Stimulant during the Transition Period Improved Lipid Metabolism and Rumination without Affecting Inflammatory Status.

摘要: Omnigen-AF (OAF) increases leukocyte functions in immunosuppressed animal models and reduces incidence of infectious diseases early lactating dairy cows, although its mode action is still unclear. This study aims to provide a wider perspective the metabolic effect OAF test potential as strategy address disorders transition period. A group 10 Holstein cows were divided into 2 groups: The treated (IMS; 5 cows) received 32.5 g twice day (65 d−1) top-dress morning afternoon feeds from −55 42 days calving (DFC), whereas control (CTR; no supplementation. From −62 DFC, body condition score, weight, dry matter intake, rumination time milk yield measured; blood samples collected weekly assess wide hematochemical profile white cell by ex-vivo challenge assays. At 30 rumen fluid was analyzed for pH, volatile fatty acids composition, urea nitrogen, lactate contents. Data submitted ANOVA using mixed model repeated measures, including treatment, time, their interaction fixed effects. decreased nonesterified beta hydroxybutyrate concentrations increased lactation. Leukocytes IMS had lower production glucose consumption after stimulation. did not reduce acute phase response indicators reduced albumin antioxidants calving, suggesting impairment hepatic related protein synthesis antioxidant management. Nevertheless, lack on bilirubin liver enzymes refutes possibility severe damage occurring with Positive effects reducing mobilization fats ketogenesis increasing suggest effectiveness preventing