Integration of positive and negative growth signals during ras pathway activation in vivo.
作者： Sheelagh Frame , Allan Balmain
DOI: 10.1016/S0959-437X(99)00052-0
关键词:
摘要: Expression of RAS proteins can have either positive or negative effects on cell growth, differentiation and death. New technologies are being developed for the generation animal models to address questions where, when how much Ras is expressed during tumorigenesis, these disparate signals integrated multistage carcinogenesis.
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Jaw-Ji Yang, Jong-Sun Kang, Robert S. Krauss, Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth. Molecular and Cellular Biology. ,vol. 18, pp. 2586- 2595 ,(1998) , 10.1128/MCB.18.5.2586
Asim Khwaja, Pablo Rodriguez‐Viciana, Stefan Wennström, Patricia H Warne, Julian Downward, Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway The EMBO Journal. ,vol. 16, pp. 2783- 2793 ,(1997) , 10.1093/EMBOJ/16.10.2783
A. I. Robles, M. L. Rodriguez-Puebla, A. B. Glick, C. Trempus, L. Hansen, P. Sicinski, R. W. Tennant, R. A. Weinberg, S. H. Yuspa, C. J. Conti, Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo Genes & Development. ,vol. 12, pp. 2469- 2474 ,(1998) , 10.1101/GAD.12.16.2469
J. A. Diehl, M. Cheng, M. F. Roussel, C. J. Sherr, GLYCOGEN SYNTHASE KINASE-3BETA REGULATES CYCLIN D1 PROTEOLYSIS AND SUBCELLULAR LOCALIZATION Genes & Development. ,vol. 12, pp. 3499- 3511 ,(1998) , 10.1101/GAD.12.22.3499
A C Lloyd, F Obermuller, S Staddon, C F Barth, M McMahon, H Land, Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes & Development. ,vol. 11, pp. 663- 677 ,(1997) , 10.1101/GAD.11.5.663
A Sewing, B Wiseman, A C Lloyd, H Land, High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Molecular and Cellular Biology. ,vol. 17, pp. 5588- 5597 ,(1997) , 10.1128/MCB.17.9.5588
Eric Stanulis, Elena Mirosh, Henry Hennings, Chuxia Deng, Stuart H. Yuspa, Wendy C. Weinberg, Aryaman Shalizi, Ester Fernandez-Salas, David L. Morgan, Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis. Cancer Research. ,vol. 59, pp. 2050- 2054 ,(1999)
C. Marcelo Aldaz, David Trono, Fernando Larcher, Thomas J. Slaga, Claudio J. Conti, Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions. Molecular Carcinogenesis. ,vol. 2, pp. 22- 26 ,(1989) , 10.1002/MC.2940020104
Nywana Sizemore, Stewart Leung, George R. Stark, Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit Molecular and Cellular Biology. ,vol. 19, pp. 4798- 4805 ,(1999) , 10.1128/MCB.19.7.4798
Iris Treinies, Hugh F. Paterson, Steven Hooper, Rebecca Wilson, Christopher J. Marshall, Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis Molecular and Cellular Biology. ,vol. 19, pp. 321- 329 ,(1999) , 10.1128/MCB.19.1.321