Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity.

摘要: Alginates are classed as a dietary fibre and have been shown to inhibit digestive enzymes in vitro, therefore could be used an obesity treatment. The current study aims assess whether alginate in bread vehicle maintains its inhibition properties despite cooking digestion, may potential treatment for obesity. After 180 min model gut that replicates digestion the mouth, stomach small intestines (AB), control (CB), CB with Manucol® DM alginate, free solution were collected. DM, LFR 5/60 SF200 heated at 37 °C 200 °C, also 50, 100 150 °C. Samples from assessed molecular size using viscosity, gel filtration lipase turbidity assay. AB does not significantly increase viscosity gut. Viscosity of reduces beyond 100 °C, although retains up Cooking into reduce or affect properties. These data demonstrate robustness alginates process digestion. Therefore adding