Novel regulatory functions for Toll-like receptor-activated B cells during intracellular bacterial infection

摘要: Infections by intracellular bacterial pathogens remain a major cause of human diseases worldwide. Despite intensive efforts, the development effective vaccines or immunotherapies against these has largely remained unsuccessful, asking for exploration new aspects host response to pathogens. Genetic studies have demonstrated beyond doubt that cell-mediated mechanisms defense involving innate immunity and T cells are crucial importance control diseases. By contrast, role B during infection so far received little attention besides their as antibody-producing cells. However, general knowledge B-cell immunology in particular antibody-independent functions greatly increased last years. Recently, it was found model Salmonella typhimurium Toll-like receptor triggering on resulted through interleukin-10 secretion marked suppression ultimately leading uncontrolled growth bacteria earlier death from disease both primary secondary infections. This article reviews protective deleterious roles infections discusses how manipulating may be powerful means therapeutically improve resistance