Bilateral neurochemical changes induced by unilateral cerebral haloperidol administration: evidence for cerebral asymmetry in the rat.

摘要: Abstract Bilateral alterations in dopamine metabolism were determined the striatum, olfactory tubercle, and frontal cortex of rats pretested for circling behavior. Dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic (HVA), norepinephrine, 5-hydroxyindole-3-acetic (5-HIAA) measured by high-performance liquid chromatography 15 min after right or left intracarotid infusion haloperidol. Concentrations DOPAC HVA significantly increased striatum ipsilateral to side haloperidol infusion, regardless whether it was left. In contrast, concentrations these metabolites unchanged tubercle a but bilateral increases evident infusion. Higher levels also apparent intravenous jugular administration Dopamine lower infusions. 5-HIAA higher following infusions These data indicate that unilateral cerebral induces asymmetric side-dependent serotonin metabolites. differences appear be due intrinsic variations sensitivity haloperidol, are not associated with direction