Apical sodium-dependent bile acid transporter, drug target for bile acid related diseases and delivery target for prodrugs: Current and future challenges.

作者: Ming Li , Qian Wang , Yong Li , Shengtian Cao , Yingjun Zhang

DOI: 10.1016/J.PHARMTHERA.2020.107539

关键词:

摘要: … target for intervention to regulate the levels of BAs, cholesterol, lipid and glucose etc. In addition, ASBT is also a popular delivery target … a target for therapy as well as a delivery target for …

参考文章(209)
Barbara Döring, Thomas Lütteke, Joachim Geyer, Ernst Petzinger, The SLC10 Carrier Family Co-Transport Systems. ,vol. 70, pp. 105- 168 ,(2012) , 10.1016/B978-0-12-394316-3.00004-1
M. Kratz, Dietary Cholesterol, Atherosclerosis and Coronary Heart Disease Atherosclerosis: Diet and Drugs. ,vol. 170, pp. 195- 213 ,(2005) , 10.1007/3-540-27661-0_6
Chunhuan Jiang, Qinglong Xu, Xiaoan Wen, Hongbin Sun, Current developments in pharmacological therapeutics for chronic constipation Acta Pharmaceutica Sinica B. ,vol. 5, pp. 300- 309 ,(2015) , 10.1016/J.APSB.2015.05.006
A. Baker, D. Kelly, P. McClean, P. Karthikeyan, P. McKiernan, A. Dorenbaum, B.M. Kamath, B. Shneider, S. Barbat, S. Medendorp, A. Raychaudhuri, C.A. Kennedy, R.J. Thompson, LO4 : A phase 2, randomized, placebo-controlled study (IMAGO) of LUM001, a novel inhibitor of the apical sodium-dependent bile acid transporter (ASBT), in paediatric patients with alagille syndrome (ALGS) Journal of Hepatology. ,vol. 62, ,(2015) , 10.1016/S0168-8278(15)30150-1
Paul A. Dawson, Role of the intestinal bile acid transporters in bile acid and drug disposition. Handbook of experimental pharmacology. ,vol. 201, pp. 169- 203 ,(2011) , 10.1007/978-3-642-14541-4_4
M.H. Wong, P. Oelkers, A.L. Craddock, P.A. Dawson, Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. Journal of Biological Chemistry. ,vol. 269, pp. 1340- 1347 ,(1994) , 10.1016/S0021-9258(17)42263-0
Richard H Ho, Brenda F Leake, Brad L Urquhart, Jamie C Gregor, Paul A Dawson, Richard B Kim, Functional Characterization of Genetic Variants in the Apical Sodium-Dependent Bile Acid Transporter (ASBT; SLC10A2) Journal of Gastroenterology and Hepatology. ,vol. 26, pp. 1740- 1748 ,(2011) , 10.1111/J.1440-1746.2011.06805.X
Elisa Lozano, Maria J. Monte, Oscar Briz, Angel Hernández-Hernández, Jesus M. Banales, Jose J.G. Marin, Rocio I.R. Macias, Enhanced antitumour drug delivery to cholangiocarcinoma through the apical sodium-dependent bile acid transporter (ASBT). Journal of Controlled Release. ,vol. 216, pp. 93- 102 ,(2015) , 10.1016/J.JCONREL.2015.08.022
David Q. Shih, Markus Bussen, Ephraim Sehayek, Meenakshisundaram Ananthanarayanan, Benjamin L. Shneider, Frederick J. Suchy, Sarah Shefer, Jaya S. Bollileni, Frank J. Gonzalez, Jan L. Breslow, Markus Stoffel, Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism Nature Genetics. ,vol. 27, pp. 375- 382 ,(2001) , 10.1038/86871