Compressive mechanical properties of the intraluminal thrombus in abdominal aortic aneurysms and fibrin-based thrombus mimics

摘要: An intraluminal thrombus (ILT) forms in the majority of abdominal aortic aneurysms (AAAs). While ILT has traditionally been perceived as a byproduct aneurysmal disease, mechanical environment within may contribute to degeneration wall by affecting biological events cells embedded ILT. In this study, drained secant modulus (E(5) approximately at 5% strain) specimens (luminal, medial, and abluminal) procured from elective open repair was measured compared using unconfined compression. Five groups fibrin-based mimics were also synthesized mixing various combinations fibrinogen, thrombin, calcium. Drained moduli determine effect components' concentrations on mimic stiffness. The stiffness native Preliminary data water content layers measured. It found that abluminal layer (E(5)=19.3kPa) is stiffer than medial (2.49kPa) luminal (1.54kPa) layers, both which are statistically similar. E(5) (0.63, 0.22, 0.23, 0.87, 2.54kPa) dependent concentration all three components: decreases with decrease fibrinogen (60-20 20-15mg/ml) thrombin (3-0.3 units/ml), increases calcium (0.1-0.01M). two not different A similar biochemical components, structure, properties would provide an appropriate test medium for AAA mechanobiology studies.