Staphylococcus aureus heme and siderophore-iron acquisition pathways.

摘要: Staphylococcus aureus is a versatile opportunistic human pathogen. Infection by this bacterium requires uptake of iron from the host, but highly restricted in environment. sufficiency achieved primarily through heme and high-affinity chelators, known as siderophores. Two siderophores (staphyloferrins) are produced secreted S. into extracellular environment to capture iron. expresses specific systems for staphyloferrins more general other microorganisms. The system uses highly-specific cell surface receptors extract hemoglobin hemoglobin-haptoglobin complexes transport cytoplasm where it degraded liberate Initially thought be independent systems, recent findings indicate that these pathways intersect. IruO reductase releases some ferric-siderophores. Moreover, multifunctional SbnI produces precursor staphyloferrin B biosynthesis, also binds regulate expression biosynthesis pathway. Intersection hypothesized important rapid adaptation available sources. Components siderophore currently being targeted development therapeutics against aureus.